Matteo Ponzoni
- Title:
- Cardiovascular Surgeon, Division of Cardiovascular Surgery
- Designations:
- MD
- Pronouns:
- He/Him
- Phone:
- 416-813-7654
- Email:
- matteo.ponzoni@sickkids.ca
- Fax:
- 416-813-7984
- Alternate Contact Name:
- Regan Nicholson
- Alternate Phone:
- 416-813-7654 ext. 415650
- Alternate Email:
- regan.nicholson@sickkids.ca
- Alternate Fax:
- 416-813-7984
- U of T Positions:
- Assistant Professor, Department of Surgery
Research Positions
Associate Scientist-Track Investigator, Molecular Medicine Program
Biography
Dr. Matteo Ponzoni is a congenital cardiac surgeon-scientist whose clinical and research interests include complex congenital heart disease, advanced heart failure, mechanical circulatory support and failing Fontan physiology. He trained in adult and congenital cardiac surgery in Italy before completing research and clinical fellowships in congenital cardiovascular surgery at SickKids. Ponzoni later returned to SickKids as a cardiovascular surgeon.
Research
Ponzoni's research focuses on myocardial regeneration and understanding the mechanisms that contribute to organ dysfunction in patients with Fontan circulation, particularly Fontan-associated liver disease. His goal is to bring together congenital cardiac surgery and translational research to develop new surgical strategies based on a better understanding of disease mechanisms. Ultimately, this work aims to improve long-term outcomes for people with congenital heart disease.
Publications
- Ponzoni M, Saleh J, Chaturvedi RR, et al. Extracardiac conduit restriction is associated with increased liver fibrosis in adolescent Fontan patients. J Thorac Cardiovasc Surg. 2026;171(2):328-337.e5.
- Ponzoni M, Yeganeh A, Zhang L, et al. Controlled Right Ventricular Pressure Overload Can Rescue Left Ventricular Dysfunction by Promoting Biventricular Adaptive Hypertrophy. JACC Basic Transl Sci. 2025;10(8):101259.
- Ponzoni M, Bertelli F, Yoo SJ, et al. Mixed reality for preoperative planning and intraoperative assistance of surgical correction of complex congenital heart defects. J Thorac Cardiovasc Surg. 2025;170(2):327-335.e1.
- Padalino MA, Ponzoni M, Castaldi B, et al. Surgical management of failing Fontan circulation: results from 30 cases with 285 patient-years follow-up. Eur J Cardiothorac Surg. 2022;61(2):338-345.
- Ponzoni M, Frigo AC, Castaldi B, et al. Surgical strategies for the management of end-stage heart failure in infants and children: A 15-year experience with a patient-tailored approach. Artif Organs. 2021;45(12):1543-1553.